JACKSONVILLE, FL, Nov. 5, 2026 — The Jacksonville Jaguars take a short week into Thursday Night Football against a Baltimore Ravens team that has lost its starting and backup quarterbacks and is trying to stop a three-game slide.

Kickoff is 8:15 p.m. ET at M&T Bank Stadium. The game is on Prime Video and NFL+, NFL.com reported. Jacksonville is 5-2 and leads the AFC South. Baltimore is 4-4 after three straight losses to AFC opponents, according to NFL.com.

Why Baltimore's quarterback room is empty

Two-time MVP Lamar Jackson is heading for injured reserve after hurting his right thumb on the first offensive play of last week's game, NFL.com's Dan Parr reported. Backup Tyler Huntley is out for the season with turf toe, Parr wrote, which leaves undrafted rookie Joe Fagnano lined up for his first career start in prime time.

The Associated Press reported that Fagnano was forced into duty last weekend when both Jackson and Huntley were unavailable, and that Baltimore was finalizing a trade with the Arizona Cardinals for veteran Jacoby Brissett. A person with knowledge of the trade told AP the deal hadn't been completed when that report was published Wednesday, so Launchpad is treating Brissett as a reported move, not a finished one.

Fagnano completed 10 of 21 passes for 91 yards with no touchdowns and one interception in that relief appearance against Buffalo, NFL.com reported. Parr wrote that the 25-year-old is dealing with an ankle injury of his own and wore a brace in Tuesday's practice. He made 44 college starts across seven seasons and threw 48 touchdowns to 6 interceptions in three seasons at UConn, according to NFL.com.

What Jacksonville brings

The Jaguars beat the Indianapolis Colts 42-7 at home last week, and Trevor Lawrence didn't play in the fourth quarter, NFL.com reported. Parr wrote that Next Gen Stats gives Jacksonville a 95% playoff probability and a 90% chance of winning the AFC South — the highest division-title odds of any team — and that the Jaguars have the easiest remaining strength of schedule (.416).

Jacksonville's defense ranks No. 2 in scoring defense and allows 15.9 points per game, WBAL reported, citing team and league figures. The Jaguars also have the NFL's No. 1 rushing defense and allow a league-low 3.4 yards per carry, NFL.com reported — though run-stuffing defensive tackle DaVon Hamilton tore a quadriceps last week and is out for the season, Parr wrote.

On the other side of the ball, Jacksonville is coming off a season-high 183 rushing yards against Indianapolis, WBAL reported. The Jaguars' own preview with NFL Network analyst Bucky Brooks described a "dynamic inside-out passing game" with receivers Parker Washington, Jakobi Meyers and Brian Thomas Jr. and tight end Brenton Strange, plus a rushing attack led by Bhayshul Tuten and Chris Rodriguez Jr.

Baltimore's plan without Jackson

With a rookie under center, the Ravens are expected to lean on two-time rushing champion Derrick Henry and their defense. Henry hasn't reached 60 rushing yards in any game during Baltimore's losing streak, NFL.com reported. Brooks wrote that Baltimore will likely turn to a run-heavy plan that shortens the game and limits how much Fagnano has to create plays.

WBAL reported that Baltimore is a 9.5-point underdog at home — its largest home point-spread deficit since a 2015 game against Pittsburgh. The Ravens' playoff odds have fallen from about 70% to 20% in four weeks, according to NFL.com. Their defense has allowed 35 points in each of the past two games, WBAL reported, and still features All-Pro safety Kyle Hamilton, Roquan Smith, Marlon Humphrey and Trey Hendrickson among its high-priced pieces.

Florida's NFL week

Thursday's game is the first of a Florida-heavy stretch. The Tampa Bay Buccaneers host the Chicago Bears on Sunday, and the Miami Dolphins visit the Cleveland Browns, according to the NFL schedule. Jacksonville will try to keep its division lead without looking past a short-handed opponent that still has Henry and a veteran defense.

Kickoff is 8:15 p.m. ET. Check local listings and Prime Video for the broadcast.

Sources: NFL.com (Dan Parr); Associated Press; Jaguars.com / Bucky Brooks; WBAL.

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